Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease

J Med Chem. 2000 Jun 15;43(12):2297-9. doi: 10.1021/jm990622z.
No abstract available

MeSH terms

  • Alzheimer Disease / drug therapy
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides / antagonists & inhibitors*
  • Amyloid beta-Peptides / biosynthesis
  • Aspartic Acid Endopeptidases
  • Cell Line
  • Endopeptidases / metabolism*
  • Humans
  • Norbornanes / chemical synthesis*
  • Norbornanes / chemistry
  • Protease Inhibitors / chemical synthesis*
  • Protease Inhibitors / chemistry
  • Structure-Activity Relationship
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / chemistry

Substances

  • Amyloid beta-Peptides
  • Norbornanes
  • Protease Inhibitors
  • Sulfonamides
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human